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Damage to the optic nerve is irreversible

Both rapamycin (classical autophagy inducer) and RSL3 can block mechanistic target of rapamycin kinase (MTOR) activation and cause GPX4 protein degradation in human pancreatic cancer cells, which can restore or enhance the anticancer activity of gemcitabine in vitro or in xenogeneic PDAC models (Liu Y

Annu Rev Pathol , 2013, 8: 241-276

Slides were dehydrated, mounted using VectaMount Permanent mounting media (Vector Laboratories, H-5000-60) and imaged using 20 bright-field objective on a Zeiss AxioScan Z.1 slide scanner